Coronavirus

Human Challenge Trials for Coronavirus Vaccines Are Ethical and Should Be Initiated Quickly

Volunteers would earn cash for the risks they take on our behalf.

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It's time to recruit some healthy young people, inject them with various experimental coronavirus vaccines, and then expose them to the virus to see if any of them work. The health of the volunteers would be monitored carefully, and they would be given access to the best available care should they need it. Besides the satisfaction of perhaps playing a role in saving hundreds of thousands of lives and hastening the end of the lockdowns, the volunteers could earn some cash for their troubles as well.

An article today in Science by the Northwestern University bioethicist Seema Shah and her colleagues lays out an ethical framework for initiating such controlled human infection studies (CHIs) to speed up the process of identifying effective vaccines and treatments for the virus that causes COVID-19. Such studies, they write,

could have high social value in several ways. For example, they could help prioritize among the almost 100 investigational vaccines and over 100 experimental treatments for COVID-19 currently in development. CHIs could help identify the most promising agents, which would inform the design of larger trials, guide decisions to scale up manufacturing early, and thereby accelerate product development and implementation. If they saved even a few months of vaccine development, [coronavirus] CHIs would contribute to faster control of the pandemic and reduce the need for, and associated costs of, physical distancing measures, providing substantial benefits for much of the world's population (including the most vulnerable).

Not least among the "substantial benefits" that CHIs could offer is a faster restart and recovery of the world's economies.

So those are the benefits. What about the risks to the volunteers? The ethicists observe that some research estimates that "healthy adults aged 20 to 29 have a 0.03% risk of death and a 1.1% risk of hospitalizations" from COVID-19. Thus, they suggest, the risks young CHI volunteers would run are similar to risks people typically take in other research and in some aspects of every day life:

Of course, CHI researchers must obtain robust and ongoing informed consent from the volunteers. The ethicists also observe that "fairness seems to demand offering participants compensation for their time." It certainly does. They propose a compensation of several thousand dollars to each American volunteer.

In an emailed press release, a coronavirus vaccine challenge working group that includes the Harvard epidemiologist Marc Lipsitch and the NYU bioethicist Arthur Caplan agreed with Shah and her colleagues. "The health and economic damage facing the world from the ongoing viral plague, especially in the most vulnerable segments of human society, are staggering," the researchers observe. "Vaccine research that could speed the process to find a safe, efficacious, and practical vaccine would mitigate this ongoing damage, and if done consistent with recognized standards of human participant protection, would be ethical." They correctly conclude that it is therefore "time to promptly fund and initiate the necessary preparations for conducting challenge studies."

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  1. Besides the satisfaction of perhaps playing a role in saving hundreds of thousands of lives and hastening the end of the lockdowns, the volunteers could earn some cash for their troubles as well.

    Do it in New York, folks! You’ll earn an *infinite* amount!

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    2. And Cuomo will not waive NY State income tax, nor DeBlasio NYC city income tax.

      A bunch of contract nurses who went out there are getting bitten by this now.

      1. Cuomo and DeBallsio should get bitten. Anthony Wiener can show where by text.

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      2. A bunch of them are getting laid off too.

  2. It isn’t even much of a risk. This stuff almost never kills people who don’t have other serious illnesses and are not over 70. Your chances of dying are close to zero if you don’t fit that description. Also, it seems the virus load has a lot to do with it as well. A healthy person under 70 getting a small virus load is incredibly unlikely to get anything beyond mild symptoms.

    I would volunteer for this and would certainly do it for good money.

    1. “Incredibly”

      I don’t believe you.

      1. There’s something wrong with you if you don’t find incredible claims to be credible.

    2. I’m unclear on if a vaccine for this strain is possible or not. As I recall, they never developed a SARS vaccine but that could just be because, well, SARS ‘mysteriously disappeared’.

      1. The weird thing about Virii… they mutate, many generations to a single human lifespan. It is why we largely treat symptoms for most.

      2. They tried before it burnt out, BYODB. It smoked a lot of the animal models they tested it on. Something like double the deaths and poor outcomes over just catching the damned thing naturally.

        Molecular Biology and Immunology have improved tremendously since 2002…but still. You first.

        1. That’s not what I’ve read. What I’ve read is that they were close to being able to start clinical trials, but then the outbreak ended and with no new cases the incentive to move forward dried up, along with any possibility of financial recompense for the cost of continuing development of the vaccine.

          Apparently the CDC does have a stock of untested vaccine

    3. Didn’t Bailey come out against paying people to participate?

      1. He also touted the FEMA model for 200k deaths. The one FEMA said wasnt realistic or ready for publishing.

        Oddly he has ignored the Ferguson model.

        1. He also ignored the Olduvai Model and the Goldilocks Hypothesis and the Ignoramati Conspiracy, and a whole buttload of other things. Don’t I look smart, by citing shit that sounds smart, without providing a link?

    4. The virus probably won’t. The vaccine?

      It had better go a lot nicer than the original SARS vaccine trials in animal models went. No fucking way would I put that shit in my body without a bunch of canaries doing all right with it first. I’d rather catch the bug.

  3. What’s this “volunteer” crap? I thought “We’re all in this together!”

    *** looks around for Mayor Pete ***

  4. yeah they better hurry before nobody’s getting sick from it anymore

    1. yea time is of the essence to bypass normal procedures so that no one notices its other flaws and before everyone realizes no one needs it

  5. I thought that younger people didn’t get it so bad either, until I heard about the 14 yo brother of one of my kid’s classmate’s who is currently on a ventilator with it. Of course there are always exceptions and they should definitely go ahead with vaccine trials. I wonder though how useful it will be by the time they have one, either there will be herd immunity or the virus will have mutated.

    1. You should call the hospital and make them aware of the studies showing ventilators may be exacerbating the issue. Main reason I dont buy your story.

      1. Why the hostility, Jesse? I buy it. I don’t think it should change policy in any meaningful way—young people die of respiratory bugs all of the time, though it’s really rare—but I don’t doubt the veracity of this particular story.

        We get too many trolls here, vomiting bullshit all over the threads. More socks than the Universe’s clothes dryer. Causes everyone to start immediately jumping to the hostile response.

      2. You should call the hospital and make them aware of the studies showing validations of the Olduvai Model and the Goldilocks Hypothesis and the Ignoramati Conspiracy, and a whole buttload of other things. Don’t I look smart, by citing shit that sounds smart, without providing a link?

        1. You though, can fuck off and leave. Sevo is right about you.

          1. Do you recall the awesome enchanter named “Tim”, in “Monty Python and the Search for the Holy Grail”? The one who could “summon fire without flint or tinder”? Well, you remind me of Tim… You are an enchanter who can summon persuasion without facts or logic!

            So I discussed your awesome talents with some dear personal friends on the Reason staff… Accordingly…

            Reason staff has asked me to convey the following message to you:

            Hi Fantastically Talented Author:

            Obviously, you are a silver-tongued orator, and you also know how to translate your spectacular talents to the written word! We at Reason have need for writers like you, who have near-magical persuasive powers, without having to write at great, tedious length, or resorting to boring facts and citations.

            At Reason, we pay above-market-band salaries to permanent staff, or above-market-band per-word-based fees to freelancers, at your choice. To both permanent staff, and to free-lancers, we provide excellent health, dental, and vision benefits. We also provide FREE unlimited access to nubile young groupies, although we do firmly stipulate that persuasion, not coercion, MUST be applied when taking advantage of said nubile young groupies.

            Please send your resume, and another sample of your writings, along with your salary or fee demands, to ReasonNeedsBrilliantlyPersuasiveWriters@Reason.com .

            Thank You! -Reason Staff

        2. Do you recall the awesome enchanter named “Tim”, in “Monty Python and the Search for the Holy Grail”? The one who could “summon fire without flint or tinder”? Well, you remind me of Tim… You are an enchanter who can summon persuasion without facts or logic!

          So I discussed your awesome talents with some dear personal friends on the Reason staff… Accordingly…

          Reason staff has asked me to convey the following message to you:

          Hi Fantastically Talented Author:

          Obviously, you are a silver-tongued orator, and you also know how to translate your spectacular talents to the written word! We at Reason have need for writers like you, who have near-magical persuasive powers, without having to write at great, tedious length, or resorting to boring facts and citations.

          At Reason, we pay above-market-band salaries to permanent staff, or above-market-band per-word-based fees to freelancers, at your choice. To both permanent staff, and to free-lancers, we provide excellent health, dental, and vision benefits. We also provide FREE unlimited access to nubile young groupies, although we do firmly stipulate that persuasion, not coercion, MUST be applied when taking advantage of said nubile young groupies.

          Please send your resume, and another sample of your writings, along with your salary or fee demands, to ReasonNeedsBrilliantlyPersuasiveWriters@Reason.com .

          Thank You! -Reason Staff

      3. “You should call the hospital and make them aware of the studies showing ventilators may be exacerbating the issue.”

        Since JesseSPAZ was too lazy to provide a link, I will do so! It isn’t ventilators that spread the virus, it is lower-tech things like CPAP machines that do that!

        https://qz.com/1833147/doctors-fighting-coronavirus-face-a-ventilator-catch-22/
        AIR SUPPLY
        Doctors fighting coronavirus face a ventilator Catch-22
        April 9, 2020

        Here is an out-take…

        “The moment the tube goes in, the system becomes closed, the spread of the virus becomes zero,”

        Plenty more details there. It’s cheaper CPAPS, not ventilators and full intubation that’s the problem, though. See this below out-take also…

        Now, he and his colleagues are looking at cheaper ways to build non-invasive ventilators that also prevent the spread of the virus in the air. In Italy, engineers have adapted full-face scuba masks into non-invasive ventilators.

        “We do not have the technology to do non-invasive ventilation while at the same time there is no spillage happening,” Rajan says. “It’s Catch-22—if you do not intubate these patients, you risk all the healthcare providers.”

        My comment: Also we need to think through the possible other ugly implications of slamming ANY “tech” that “helps spread the virus” in this manner. Allowing virus patients to breath spreads the virus! Killing them like anthrax-infected cattle or “mad cows”, or African-swine-flu pigs… THAT would help stop the virus! Like wiping out entire communism-infected villages in Vietnam… Some American military officer supposedly once said, “We had to destroy the village to save it”. I for one do NOT want to go there! Else, no one will want to go to the hospital to get killed, and CPAPS will become black-market crime sources!

  6. They are making the wrong risk comparisons. How about:

    Risk of sticking it in crazy.
    Risk of selling loosies in NYC.
    Risk of protesting the lockdowns.
    Risk of pursuing unorthodôx faiths while having weapons in your compound.

    1. What about the risks associated with blowing upon a cheap plastic “lung flute” in the USA, which, alone among all of the nations in the Local Mega-Galactic Clusterfuck, demands that you obtain the permission of a Certified (AND certifiable!) Doctor of Doctorology, before blowing upon said UTTERLY DANGEROUS medical instrument of mass destruction and death?!?!

      BE YE HEREBY AND ALWAYSBY BE WARNED that USA citizens and residents shall NOT blow upon the Dreaded Lung Flute, w/o proper blessings, prescriptions, and conniptions bestowed upon thou, by a properly Government-Almighty-blessed Doctor of Doctorology!!!

      In these here dangerous days, STAY THOU SAFE from the Flute Police!!!!

      To find precise details on what NOT to do, to avoid the flute police, please see http://www.churchofsqrls.com/DONT_DO_THIS/ … This has been a pubic service, courtesy of the Church of SQRLS!

  7. This seems to be an exceptionally expensive way to do drug tests. I have a faster idea
    1 institute the draft
    2 draft latter day st
    3 say they can go to the army or to the medical branch

    See we can revive operation white coat! Hell include the Christians and the ortodox jews in this, because they are clingers too, and if they die… Well all religious people are bigots and deserve it!

  8. I suppose even if the vaccine doesn’t work, they’ll get it over with and can resume “normal” life.

  9. The ethicists also observe that “fairness seems to demand offering participants compensation for their time.”

    Well, there you have it. Obviously, only people who are desperate for money are going to be coerced into risking their lives for petty cash, and we all know what that means. RACIST! “Ethicists” should more properly be called what they are, Nazi eugenicists, white supremacists cloaking their genocidal intent behind the label of “science”.

    And, no, I didn’t copy/paste this from somebody’s twitter account, but I’d be willing to bet that within 24 hours you’ll be able to find this statement made almost word-for-word on the twitters if it’s not already there.

  10. I suppose if these participants are not only allowed to take on this risk but also get paid for it, I should be able to go to a fucking restaurant. You don’t even have to pay me.

    1. This. I’d love to go back to a few favorite bars.

    2. “I should be able to go to a fucking restaurant.”

      I approve of this remark! They took away our right to “peacefully assemble” at restaurants and a boat-load of other places, and never even bothered to amend the USA Constitution!

      Never let a good crisis go to waste! Always grow Government Almighty!

  11. How about a humanitarian approach and “volunteer” all those prisoners who are gonna get it anyway.

  12. How about offering it to “essential” workers, who are more exposed to it and aren’t get any extra pay? Outside of simply having a job

  13. The damn is breaking. People are done, or at least enough people are done. Dem governor Polis, Co, is reopening. Even Cuomo is saying it can’t last forever, because, you know, it can’t.
    Also, this is what happens when Karen gets old enough to be politically powerful.
    Also, LIBERTARIAN MOMENT!!!eleventyone!!!!!aaaaaa!a!!

  14. Can politicians be conscripted as guinea pigs?

  15. 20-29? Booooo.

    Let’s make it 20-39, I want free thousands for getting something injected that’s less risky than how I live already. Mortality for my age group is still 0.2%, so let’s go.

    1. You could start a reality show called “You can’t take it with you”.

  16. Having “high social value” does not meet the criteria of ethics.

    1. And “Heil Rob Misek” doesn’t believe that Jews have enough of a “high social value”, that they, and history, should be believed, when they (Jews) say that they lost many-man personal friends and relatives to NAZI butchery. “Heil Rob Misek” doesn’t believe that the Holocaust was real! Everyone should know that, FYI for all readers… “Heil Rob Misek” doesn’t deserve to be believed!

      1. Some dipshit lying Jew here, regaled us with his gramps story about his job taking the bodies out of the gas chamber.

        Then I shared the science. That the cyanide that would have coated the bodies is absorbed through the skin and his lying gramps would have died after his first trip.

        Lies are easy to expose with logic and science.

        That must be why it’s a crime to objectively review the evidence in every nation where the bullshit holocaust allegedly occurred.

      2. SQRLSY

        C’mon you been around. Don’t feed the trolls.

        1. Scaredy bigot won’t consider the science.

          Fuck off.

  17. Mr. Bailey…Tell you what. You go first.

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