CRISPR Mustard Greens Test America's Appetite for Designer Veggies
The North Carolina–based biotech startup Pairwise will begin selling genetically modified and better-tasting mustard greens.

If you've ever wanted to eat mustard greens raw without experiencing the dreaded burning "mustard bomb," gene-editing technology will soon give you the chance.
North Carolina–based health-food startup Pairwise used CRISPR to develop a new type of mustard greens that is less bitter and pungent than the traditional version but has the same nutritional value. The company's crops will soon be available in restaurants in the Minneapolis–St. Paul region, St. Louis, Missouri, and Springfield, Massachusetts. The greens are slated to be available in grocery stores this summer, likely beginning in the Pacific Northwest.
CRISPR targets and cuts genetic material to manipulate the code of organisms, enabling the suppression of some traits and the enhancement of others. In a report on its work, Pairwise said it altered the DNA of mustard greens until its trials achieved "a stable reduction in pungency in edited plants across multiple environments." Before the company's successful CRISPR trial, the report noted that minimizing "undesirable attributes associated with leafy greens" required cooking the leaves, which reduced the plants' "nutrient quality."
Pairwise's gamble is that if mustard greens can be made to taste good raw, consumers would eat them that way instead of boiling away their nutritional value to make them palatable. Given that cooked mustard greens are popular in Asian and Mediterranean cuisines, selling them as a salad ingredient could expand their market.
This goal means that Pairwise must appeal directly to consumers in a way that most companies generally don't when changing the DNA of an agricultural product. Companies that sell crops adjusted with genetically modified organisms (GMOs) to increase crop yields are pitching farmers and agribusinesses, not grocery stores and restaurant customers. Furthermore, most companies would rather advertise that their products are free of genetic modification.
Pairwise will have to convince consumers who are often reluctant to try bioengineered foods. "Most people don't have a lot of knowledge about GMOs…if they were to see a label about them, they would likely be averse to them," Jayson Lusk, an agricultural economist at Oklahoma State University, told The Washington Post.
That said, CRISPR tech itself may give the company an advantage. A brief by the Food and Drug Law Institute noted that CRISPR uses DNA "from nature-generated genetic variations within the crop itself, and not from another reproductively incompatible organism." This fact led the U.S. Department of Agriculture (USDA) to open the door to CRISPR since it avoids the bioengineered label of GMO products.
In 2018, then–Secretary of Agriculture Sonny Perdue declared that the USDA "does not regulate or have any plans to regulate plants that could otherwise have been developed through traditional breeding techniques as long as they are not plant pests or developed using plant pests." Therefore, Pairwise was able to move forward with little hindrance.
"In the past, many of the [genetically modified] or gene-edited improved traits benefit farmers, with consumers not realizing the indirect benefits of reduced food costs and enhanced farming practices," says Paul Ulanch, senior director of focused initiatives at the North Carolina Biotechnology Center. "Consumers have embraced improvements to produce foods in the past, such as seedless grapes and melons. I anticipate consumers will embrace foods that have been modified via precision gene editing that offers additional value, such as improved nutrition, flavor, and shelf life."
CRISPR technology has the potential to create better-tasting and healthier food, and the USDA's ruling will allow mustard greens to meet their fate in the free market. By releasing the greens to market, consumers, not regulators, will determine whether Pairwise will turn a profit.
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I’m sure it will be a hit. Everyone loves mustard greens.
Reason 2015-2016:
“Everything is possible with CRISPR,” the Baylor geneticist Hugo Bellen told Science News this week. “I’m not kidding.” … For example, Chinese researchers are using CRISPR in an attempt to boost immune responses in lung cancer patients. American researchers are soon to follow. CRISPR could be used to ameliorate a whole variety of genetic diseases. The gene-editing technique has successfully reversed aging in human cells. Crop scientists have used CRISPR to develop mushrooms that resist browning; cucumbers that fight off disease viruses; and wheat that is protected against powdery mildew. Since no new genes are added or subtracted, anti-biotech activists will have a hard time arguing for the application of deadening hand of regulation to the new crop varieties. CRISPR editing will also enable breeders to produce disease resistant livestock and enable sex selection so that only male calves (more meat) and female chickens (more eggs) are born.
Want to eliminate disease-carrying mosquitoes or introduced species from the landscape? CRISPR editing can create gene-drives that make sure that both copies of a targeted natural gene in sexually reproducing species are replaced with the engineered version. For example, a suppression gene-drive could bias the production of sperm containing Y chromosomes, so that only males are born. The spread of the Y-drive would result in a population crash of the targeted species. That would be a great way to get rid of the non-native mosquito species that carries the Zika virus.
Reason 2023:
If you’ve ever wanted to eat mustard greens raw without experiencing the dreaded burning “mustard bomb,” gene-editing technology will soon give you the chance.
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In other words, if you can make them taste like something else, people will eat them.
What's the point?
More green-eating, of course.
Because spinach is too boring for foodies. They're looking for the next kale
I have never wanted to eat mustard greens raw, but otherwise fascinating.
Right now, makers of lab-grown meat are trying to make it taste like the real thing. I predict they will eventually realize they don’t have to stick to imitation, but instead can boost the flavorful elements beyond the real thing. Or even invent new types of “meat”.
Except that lab grown meat is much worse in terms of “pollution” than the tasty cow
And seed oils are bad for you.
Yes, fight millions of years of evolution and create a new taste.
I bet you believe the human immune system is a thing too.
Humanity has been "fighting evolution" for 10k years at least. Compare domesticated animals to their closest wild relatives. Better yet, look at the wild ancestors of many, many cultivated plants. In a whole lot of cases, you probably wouldn't realize they're even related.
Ethical long-pig.
Sure, why not!
The thing I never liked about greens in general is that you buy them in big, fluffy bunches that can’t fit in a single grocery bag, but when you get them home and boil them, they shrink to the very bottom of the pot.
I’d love it if CRISPR could tweak the green genes (see what I did there?) so they kept most of their size. Perhaps making them better raw is a step in this direction.
You need to eat more artichokes - there is more artichoke after you've eaten one than before.
And somehow everything is covered in butter when I'm done. I've never figured it out.
Greens are great in a big bag. They will wilt by the time you get home so they are no good raw. So cook them. As creamed spinach or somesuch. Great keto food.
The reason to eat mustard greens is because you like mustard greens. If you want to eat lettuce - eat fking lettuce you dumb fk.
Spot on, Eeyore!
One word - NO.
I would be happy to try them. If they taste good, I will eat them.
Genetic modification does not concern me in the least.
What’s the worst that could happen?
Irradiating seeds never produced any vegetable kaiju, so I'm not too worried about a much more targeted approach.
I know! Let's get CRISPR connected to AI and just see what happens!
It will make the Wuhan Bat Lady look like an amateur!