We Could Be Vaccinating Twice as Fast. The Government Won't Allow It.
"Let's do the thing, which saves the most lives," says economist Alex Tabarrok: Instead of holding back second doses, use them all right away.
HD DownloadThe COVID-19 vaccines made by Moderna and Pfizer/BioNTech were developed and brought to market at a blistering pace, but their distribution has been hobbled by poor planning and rigid eligibility rules. The rollout was centrally planned in a way that didn't give local officials and health care workers enough flexibility to adjust to the realities on the ground—and to make tradeoffs between treating as many people as possible and strictly adhering to the rules.
The most recent data from the Centers for Disease Control and Prevention (CDC) show that of the more than 30 million doses shipped, only about 11 million have been used. And those are mostly first doses: The Pfizer/BioNTech and Moderna vaccines are both given as two identical shots, three and four weeks apart respectively. To ensure everyone who received the first dose is guaranteed a second one at the prescribed time, the government stockpiled one dose for every one shipped.
Alex Tabarrok, an economist at George Mason University who blogs at Marginal Revolution, has been promoting an idea called "first dose first," which the United Kingdom recently adopted. This approach would allocate all available vaccines to be used as first doses, while pushing off second doses for weeks (or even months) until production can catch up.
"That means you can give twice as many first doses," says Tabarrok, who consulted with the Trump administration, the World Bank, and foreign governments on optimal ways to incentivize rapid development of a COVID-19 vaccine. "You can have two people who are protected at an 80 percent efficacy rate, as opposed to one person who's protected at a 95 percent efficacy rate."
This week, the Trump administration reversed course on stockpiling doses, announcing that all doses held in reserve would be shipped. But there are no plans to follow the U.K.'s approach of vaccinating more widely by pushing off the second dose.
Tabarrok attributes this to a failure to think in terms of tradeoffs.
"What economists are good at," he tells Reason, "is making decisions under uncertainty and scarcity. And, it's being hard-nosed in…thinking about probabilities, thinking about risk, expected value."
"Economists are very good at saying, 'let's do the thing, which saves the most lives.'"
Produced by Isaac Reese, with production help from Paul Detrick, Ian Keyser, and Regan Taylor
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Everybody's a fucking logistics genius now.
And an expert in virology and immunology.
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We must listen to the science! Except when Joe Biden tells us to ignore the science, in which case we must listen to Joe Biden.
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SleepyJoe is the virus.
" Sleepy Joe" is not that sleepy, obviously. He's pretty alert and aware, in fact.
Although 3% of Americans have received covid vaccines in the past 6 weeks, 5 - 10 times more Americans have/will acquired immunity via covid infection during the same 6 weeks, and far more did so during the preceding 9 months.
While studies (including ones by CDC and TX Health Dept) have found/estimated that 3 – 10 times more Americans were infected with covid than have tested positive, due to increased testing in all states, that ratio now appears 3 - 7 times. So about 5 times more Americans are being infected for everyone who tests positive.
Herd immunity occurs rapidly after two thirds (65% - 70%) of people (in families, workplaces, communities, counties and/or states) have been infected or vaccinated. But even if/when/after half of people have been infected or vaccinated, the risk of new infection declined by 50+%, which is now occurring in thousands of communities, hundreds of counties and dozens of states, led by the Dakotas.
So by the time 10% of Americans receive covid vaccines, herd immunity will have already protected most Americans from covid.
But Big Pharma, Democrats and left wing news media propagandists continue to deceive Americans to believe that herd immunity can/will only be attained via mass vaccinations.
98 US counties now have surpassed a 13% covid rate, and appear to have already (or within days or weeks of) achieving herd immunity, long before vaccines will have an impact. (Data as of 1/15/2021)
Crowley, CO – 28.8%
Dewey, SD – 23.0%
Norton, KS – 21.8%
Lincoln, AR – 21.8%
Bon Homme, SD – 21.5%
Bent, CO – 21.4%
Chattahoochee, GA – 21.2%
Trousdale, TN – 20.7%
Lake, TN – 20.6%
Buffalo, SD – 20.4%
Buena Vista, IA – 19.6%
Eddy, ND – 18.2%
Ellsworth, KS – 18.1%
Dakota, NE – 17.9%
Jackson, AR – 17.7%
Childress, TX – 17.5%
Alfalfa, OK – 17.4%
Lee, AR – 17.1%
Lafayette, FL – 16.9%
Foster, ND – 16.7%
Nobles, MN – 16.6%
Big Horn, MT – 16.6%
Seward, KS – 16.5%
Hale, TX – 16.5%
Menominee, WI – 16.4%
Lassen, CA – 16.4%
Pawnee, KS – 16.1%
Sheridan, KS – 16.0%
Logan, CO – 16.0%
Ford, KS – 15.8%
Walsh, ND – 15.8%
Wayne, TN – 15.6%
Texas, OK – 15.6%
Aurora, SD – 15.5%
Lee, KY – 15.5%
Morton, ND – 15.3%
Stutsman, ND – 15.3%
Potter, SD – 15.2%
Yuma, AZ – 15.1%
Nelson, ND – 15.0%
McKinley, NM – 14.9%
Santa Cruz, AZ – 14.8%
Lyman, SD – 14.7%
Burleigh, ND – 14.7%
East Carroll, LA – 14.7%
Lubbock, TX – 14.6%
Benson, ND – 14.5%
Dickey, ND – 14.5%
Sioux, ND – 14.4%
Davison, SD – 14.3%
Chicot, AR – 14.3%
Lincoln, CO – 14.2%
Madison, ID – 14.2%
Rolette, ND – 14.1%
Toole, MT – 14.0%
Crocket, TX – 14.0%
Cass, IL – 14.0%
Oglala Lakota, SD – 13.9%
Plymouth, IA – 13.9%
Griggs, ND – 13.8%
Finney, KS – 13.8%
Nemaha, KS – 13.8%
Colfax, NE – 13.8%
Faulk, SD – 13.7%
East Feliciana, LA – 13.7%
Lawrence, IL – 13.6%
Beadle, SD – 13.6%
Minnehaha, SD – 13.6%
Woodward, OK – 13.6%
Douglas, SD – 13.5%
Haywood, TN – 13.5%
Stark, ND – 13.5%
Lamb, TX – 13.5%
Gove, KS – 13.4%
Fayette, IL – 13.4%
Grand Forks, ND – 13.4%
Scurry, TX – 13.4%
Kearny, KS – 13.3%
Crawford, IA – 13.3%
Ramsey, ND – 13.3%
Potter, TX – 13.3%
Republic, KS – 13.2%
Golden Valley, ND – 13.2%
Whitfield, GA – 13.2%
Sanborn, SD – 13.1%
Henry, IA – 13.1%
Culberson, TX – 13.1%
Maverick, TX – 13.1%
Dodge, WI – 13.1%
Coddington, SD – 13.0%
Sevier, AR – 13.0%
Pickett, TN – 13.0%
Obion, TN – 13.0%
Sioux, IA – 13.0%
Jones, IA – 13.0%
Towner, ND – 13.0%
Madison, LA – 13.0%
Clinton, IL – 13.0%
20 states with the highest covid case rate (i.e. positive tests) are
https://www.npr.org/sections/health-shots/2020/09/01/816707182/map-tracking-the-spread-of-the-coronavirus-in-the-u-s#curves
ND – 12.5%
SD – 11.9%
UT – 10.0%
TN – 9.9%
RI – 9.9%
WI – 9.7%
IA – 9.6%
NE – 9.4%
AZ – 9.0%
AR – 8.9%
KS – 8.9%
OK – 8.8%
IN – 8.7%
ID – 8.6%
AL – 8.5%
WY – 8.5%
IL – 8.4%
NV – 8.4%
MS – 8.3%
MT – 8.3%
Holman Jenkins amplified my argument in WSJ this week
https://www.wsj.com/articles/maximize-the-vaccine-11610494003?mod=opinion_lead_pos9
excerpt
Sen. Rand Paul was assailed for tweeting that his own natural infection was more than 99% protective against future illness, compared with 94.5% for a vaccine. He was not recommending people go out and indiscriminately spread the disease. But once you accept that we’re not just one or two preachments away from solving the problem of Covid with mask-wearing, it’s time to be grateful for the one upside of infection. “Herd immunity” was a taboo term when paired with the word “strategy” but needs to rehabilitated now as a description of the goal that both vaccine and natural spread are helping us achieve.
The U.S. will soon reliably be vaccinating a million people a day but natural infections, by conservative estimate, were already putting a million a day in the U.S. on the path to natural immunity, though only a fifth of them showed up for testing.
Either kind of immune response is considered almost sure to prevent serious illness from future infection. Less certain is whether either also prevents transmission. But as epidemiologists such as Yale’s Harvey Risch and Brown’s Ashish Jha independently predicted, new cases in the Dakotas are starting to fall precipitously with perhaps half their populations having experienced Covid 19.
The practical implications are obvious. Don’t spend vaccine in the short term on people who have already been exposed if at all possible. A second implication: Unlike other countries, the U.S. has been strangely resolute in pretending that “confirmed cases” are the measure of the epidemic. Seldom has there been a clearer test of how the media sets the agenda for politicians. The press repeats this misleading statistic a thousand times a day to no real purpose, leaving us only less certain where we stand in the herd-immunity race. Underplaying the disease’s true prevalence, we have (without realizing it) conditioned people to be less careful even as we preach at them to be more careful. We cause them to underestimate their exposure risk and overestimate their death risk. Now we’ve put ourselves in the weird position of being unready to use vaccines optimally to stop the epidemic as soon as possible. We find it hard even to admit to ourselves that natural immunity is helping to bring our goal within reach.
I have been doing the math and watching the charts on this repeatedly since early December, and I believe you are spot on. Over the coming next 4 weeks, we will see a substantial drop in those areas hitting herd immunity (pretty much anywhere with a 15-20% confirmed infection rate)
There will be a few holdout areas where there haven't been the same levels of infections (Oregon, Washington, Vermont, Hawaii, etc) that will probably rely on the vaccine for herd immunity. But most other places in the US will be hitting herd immunity the hard way shortly. Especially if there really is a more virulent strain becoming prevalent.
This is why I believe that all the pro-lockdown governors are starting to plan and impliment the easing up restrictions during the period when when we are at the worst for cases and infections, and vaccines are literally going to take a year to be administered to get to that herd immunity level.
Expects KNOW we are getting close, but it would also be somewhat irresponsible to go out announcing that going the way of the Dakotas is a great idea.
The US is close to 50% immune by all estimates of actual infections in comparison to confirmed infections.
That isn't even counting the 10M people who have gotten a vaccine dose.
I believe that them giving the vaccines to the previously infected along with the at-risk, will be looked back on in history with derision and scorn.
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The US is close to 50% immune by all estimates of actual infections in comparison to confirmed infections.
Cite the actual estimate. PCR test stuff is NOT remotely an estimate of immunity though it can be cobbled into an estimate of current contagion - but that sort of estimate is not REMOTELY 50%. More like 1% (% positive * % of population tested) in a weekly or so timeframe. Can't just add those up over time either
"So by the time 10% of Americans receive covid vaccines, herd immunity will have already protected most Americans from covid."
Which they will take as proof that the vaccines worked! And be ready for the next set of lockdowns and government as savior vaccine.
You’ve got a partially tested vaccine that you have no data on beyond a few months.
I got my first dose on 1/5 and don’t consider myself to be at all vaccinated.
I understand the theory and the desire, it if you go to the one dose and you’re wrong, you’re gonna fuck up the entire vaccination program. Too big a risk. Stay with the plan.
Of course they won’t because Biden has to differentiate from Trump.
". Stay with the plan."
And throw a significant fraction of the available doses in the trash because they very short shelf life once thawed, and you only had 5 patients who qualified in accordance with the plan but one bottle is 10 doses so you have to throw 5 doses in the trash. Great plan.
That’s not what I said at all.
I’m saying stick with two doses. Nowhere did I say doses should be wasted.
Yours is another argument against the change. If the incompetent states are not able to effectively vaccinate people as is, why send them additional first doses to waste?
You said stick with the plan. The plan is a lot more than just two doses and includes very restrictive priority queues on who can be vaccinated.
That’s not right. The plan is to distribute to the states and lit the states distribute from there.
It’s the states (some of them, not all) that are coming up with garbage rules causing waste. The change from two doses to one has no bearing on that.
Do you just Jill to argue? You’re making up shit and trying to pick a fight over it. Find someone else, I ain’t interested.
Other than this, though, socialized medicine really is the most efficient.
yeah, it would be awful if the doses were for sale to the highest bidder, and companies were incentivized to roll them out and deliver them, and rich people or charities could get doses for the poor and elderly
There is more to incentive than profit CE.
The medical nerdy types want to win. There is enough money to do the job. That is important.
Going to watch the Cleveland Browns play today. You can pay Mayfield or Beckham twice as much but you will not get any better than what they are already doing.
This is not a box of cornflakes.
"There is more to incentive than profit CE."
Other than profit and not getting thrown in a cage, what incentive would there be to spend all your money curing other people of a disease you can get immune to?
And why wouldn't such do-gooders want to set up a government to manage this so they don't have to?
Are there many billionaires with private CDCs out there to keep on top of all the viruses?
Government bought these production runs. You're saying the customer should have no control over the distribution of their product to that customer?
Yet another reason why anti-gummint libertarians are such idiots. there is a lot of stupidity and bureaucracy in government BEING a customer and nowhere near enough googoo (good government) and reformist accountability. But your approach has nothing to do with the market and everything to do with increasing corruption. Which is exactly the wrong approach.
Israel.
And the "80% efficacy rate" is based on what?
https://www.fda.gov/media/144245/download
Thanks, yes, I've read that report. I'm just wary about making a drastic change in policy using data from a very small subgroup with a short follow-up.
The data are compelling (7 cases in the vaccine group compared to 39 in the placebo group, out of about 1000 participants per group) but the median follow up was only 28 days.
^
This was only what it was.
A response from the FDA to an emergent epidemic. Well reasoned and correlated to available data.
You know how to read this.
80% is also the % of people who A. Have not had Covid 19 yet and will B. Be asymptomatic when they do get it.
So, in other words, at this late, late stage in the Gumperts Curve of Coronavirus fatalities, about 160,000,000 Americans have contracted this virus to date (380,000 Covid deaths is equal to 0.24% (Infection Fatality Rate) x 160,000,000).
Only 100,000,000 more need to contract it for us to be well at herd immunity. 50% of these remaining folks will be asymptomatic.
50% of 100,000,000 is 50,000,000.
330,000,000 (U.S. Population) x 20% (the non-effective vaccine group) = about 67,000,000 who Big Pharma says will "still show symptoms even with vaccine).
Pretty darn close to 50,000,000...
Again...at this ridiculously late state of this virus, where we are at or very near natural herd immunity, rolling out a vaccine is a pretty good bet if your goal is to show the world that your product has saved humanity.
Math is our friend people. Learn it, live it, love it...
Only for the Moderna vaccine based on the number of people who got COVID-19 after the first dose and before getting the second four weeks later. I don’t think there is any data on efficiency if you didn’t get the second dose on time. So there isn’t any science to say get first dose and the wait months before getting the second will give you 80% during that period or even getting 95% if you wait months between shots.
Pfizer is even worse. https://www.bmj.com/content/371/bmj.m4826
Only 52% after first dose with 95% credible interval 29.5% to 68.4%.
Of course, the “Give everyone the first shot out of existing stock, and the second shot out of newly manufactured vaccine” plan assumes the vaccine for the second shot will be available timely.
So that is correct. It does not need to be an assumption. The contract can be based on solid evidence.
We must keep in mind that socialists never can deliver on production promises, and we just turned the country over to the socialists.
why haven't I heard more about this: Pierre Kory, M.D on the effectiveness of ivermectin on Covid.
"It basically obliterates transmission of this virus, If you take it you will not get sick"
https://www.youtube.com/watch?v=Tq8SXOBy-4w&list=WL&index=6
Instead of using drugs we already have with months of practical testing against this virus, we rush and begin administering and untested, limited "treatment". WTF
Follow the money. Always, always follow the money. Therein is the answer...always.
No no central planning works, the democrats told us so.
Follow the science they say...
For pfizer and moderna vaccines, two dose regimens were designed, proposed to the fda, tested, vetted by the fda, and marketed as two dose regimens.
The informed consent document describing the risks/alternatives/benefits, a document that must be consistent with drug safety labeling as approved by the fda, is presented to the patient.
Can't just start making stuff up on the fly, solely because what you want is not what is reality.
If you want a one shot solution, then choose the johnson and johnson version which has been designed, tested, and approved as such.
Good post.
https://www.fda.gov/media/144245/download
It is all there in table 13
The Bread Lines are HERE!!!!
The vaccines should not have been publicly funded. The only valid role which the government could have in this situation would be to prevent companies from lying about the products they are selling. They have explicitly abdicated this role by indemnifying the companies which produce vaccines from civil litigation. People should be allowed to purchase any pharmaceuticals they desire, and companies should be able to sell them for whatever price consumers are willing to pay, without needing a prescription. If vaccines had been left to the private sector, then they would have been deployed more rapidly and distributed more efficiently to those who need them and would have had a lower net cost to society as a whole. Government involvement in this pandemic has only resulted in more deaths and more destitution. Every congressperson has blood on their hands.
The protesters at the capitol did not intend to inflict physical violence upon our leaders, but they would have been morally justified if they had.
“ indemnifying the companies which produce vaccines from civil litigation.”
I have news. Without indemnification no one is going to make vaccines. The profit margin is too low.
They would but you would need to wait 2-3 years longer. It is about liability not profit margin.
The way it should work:
Companies make a product. They advertise what they know about the product and are honest about what they don’t know about the product. They do not attempt to deceive purchasers. They can charge whatever they want and sell to whomever they want. It doesn’t have to be safe. They just have to be honest about what they’re selling.
If a company isn’t honest, and it can be proven, they should be punished.
I know, it’s unrealistic. Government officials don’t want to give up their control or their ability to signal virtue. Ignorant voters will want their leaders to “do something” when anything goes slightly wrong.
Biden promises to fix this by centralizing the planning.
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Tabarrok attributes this to a failure to think in terms of tradeoffs. "What economists are good at," he tells Reason, "is making decisions under uncertainty and scarcity. And, it's being hard-nosed in…thinking about probabilities, thinking about risk, expected value." "Economists are very good at saying, 'let's do the thing, which saves the most lives.'"
Problem is he is not defining the tradeoffs well. It is not about 'lives' as mere fatalities. It is about lives as they are being lived v as they could be lived if there were enough vaccines to reach herd immunity so that it becomes endemic.
Maybe for those over-80, the fatality rate is so high that it itself dominates the 'lives' measure. For those under-65, the 'lives' measure is going to be dominated by the work/livelihoods that are being destroyed and the public debts/etc being incurred. Far more so than the mere fatality or even long-term medical harm.
It may well be that the 60-80 group actually has a low enough fatality rate to reduce its expected value of getting the vaccine below say the 45-60 group if 2020 virus stuff has produced more 'changes in workplace' than 'changes in retirement'.
Here is a perfect example of how a different approach to vaccination targeting can be rationalized - by an economist. There is no such thing as THE thing.
Indonesia is poor and doesn't have access to unlimited money printing to get more. They do understand public health - so insist on universal access to vaccines without rationing by price. And Indonesia targeting 18-59's for first stick.
What is all this fuss about vaccines? One shot, two shots, a full magazine, it doesn't matter.
We have almost a full year showing that a simple piece of cloth, properly worn over the mouth and nose (or not) is all that is necessary.
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why do people keep pushing this one shot nonsense....... we have absolutely no idea how long the immunity from one shot lasts, because it was never studied...... because these vaccines were not designed to be given as one shot......
it is likely that the immunity response will drop quickly with one shot. if you give everyone one shot, most of them might no longer be immune by the time you finish doing it.
you want to talk about getting this done quicker? start talking about the other vaccine already being used in other countries..... made right here.... that the FDA is sitting on their hands with. talk about rapid release of self testing kits to free up the healthcare staff dedicated to processing those. (we have people swabbing noses that could be giving shots instead.) stop pushing a completely untested theory that creates a great deal of risk if it is wrong.
It is all there in the white paper Pfizer prepared linked by Chipper.
Efficacy between dose 1 and 2 dropped to 53%. Efficacy after 7 days following dose 2 went to 95%.
Testing so very early results but scientists in Israel collaborating with Chinese groups think they have a one minute breath test.
https://pubs.acs.org/doi/abs/10.1021/acsnano.0c05657
but they did not give anyone one shot and never a second. we know how high the effectiveness is at 2 and 3 weeks..... and we have no idea what it is after that. we have seen studies demonstrating a fast reduction in immune response particularly in asymptomatic cases. a highly likely scenario is that we would see the same with one shot of a two shot vaccine. we do not know if they will maintain that level of immunity for a long period of time, and we have good reason to believe they will not...
also.... your link is for detection of covid, and completely irrelevant to the conversation.
The CDC put out some data right before Thanksgiving, and some of the media reported on it (NPR…for one). By Nov. 20th, the CDC estimated that there may have already been about 100,000,000 infections in the U.S. Few other media sources reported on this data.
Today, using the same CDC metric, we are nearer 160,000,000 at the least.
The math is actually quite easy, and we can figure this way:
We know the infection fatality rate (IFR) is around 0.24% (CDC data, not mine). It is likely lower, nearer to 0.15% perhaps.
We are at 380,000 Covid deaths in the U.S. So, the missing number we need is “out of how many infections”.
380,000 Covid Deaths is 0.24% of about how many?
Our answer is about. 160,000,000 infections in the U.S. to date.
And, this assumes that the Infection Fatality Rate (IFR) is as high as 0.24%. It is likely closer to 0.15%. If the latter IFR is used, we are closer to 250,000,000 infections to date, and we have reached herd immunity.
If we've reached herd immunity, why are people I know still getting sick? Herd immunity means you can go around other people with no risk of contracting the virus. That's what it means. Do you know that?
because all these people trying to make these claims are stringing together outdated, inaccurate, incomplete, or flat out made up statistics.... cooking them with some unchecked assumptions, and trying to reach conclusions not supported by actual data. people have a hard time grasping when the facts do not fit their desired reality, so they make up their own.
this is what happens when people who have no fucking clue what they are talking about are treated like they do, because it feeds other people's confirmation biases.
The numbers are what they are. We know the IFR, we know the deaths from covid to date, so figuring the # infected to date is a 4th-grade math problem.
reread what i said.... you don't know what you are talking about, and you are distorting and oversimplifying to create a reality that is not true.
Are they sick with covid? Or have they tested positive for covid with a PCR test?
This varies across regions, of course, but we are at, or near, effective herd immunity.
The numbers are what they are.
Kind of a bitch move to whine about what someone does with things they bought with their own money. Or is the idea that you want government to buy all the vaccines, you just don't want them deciding what to do with it?
How about we apply proper libertarian logic to the problem. A virus is not a human agent, and therefore, for some reason, there's nothing government should do about it. Let the free market decide who's immune and who is dead.
That's the height of moral responsibility in all other contexts, why not this one? Could it be that libertarianism is absurd and all its practitioners are full of shit?
Mr. Reese, you are more than welcome to my dose. Because they won't get that shit anywhere near me. If a person chooses to be a guinea pig and risk possible consequences far worse than a flu bug, that's your business. Personally, I don't understand laws against suicide. It's your body, your life. Want to end it, that should be your choice.
Oh yes, that's the ticket. https://www.youtube.com/watch?v=GotVR8ro9OA&feature=emb_logo&ab_channel=UrsacheundWirkung
This is a terrible idea. This will allow the virus to adapt to the vaccination and mutate. It's equivalent to not taking all of your antibiotics.
https://jlund.substack.com/p/the-covid-vaccine-could-backfire
'let's do the thing, which saves the most lives.' ...Translation: 'We gotta make a buck outta this somehow!'
Using all the available vaccine in a 1st round is as dumb an idea as grinding your seed corn and grain into cornmeal and flour and eating it.
The vaccines have been tested to work best with a booster shot a specific time after the first shot. There's no way to manufacture all those second doses in that time frame.
There are other double dose vaccines where if the booster is late or isn't given at all, it may not provide any protection.
Using all the second doses for first doses risks wasting all of the vaccine for stupid political points scoring while doing little to nothing for the people getting the shots.
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I manage a veterinary hospital and we administer a lot of vaccines that need a two or three initial dose series. If people treat themselves like they do their pets, over half of them won't be back for a second dose. Even if the government wanted to keep a reserve for second doses, keeping a 100% reserve is silly.
Why oh why would you want to be injected with all sorts of chemicals that produce very bad effects in the human body? This 'stuff' hasn't been approved by the FDA fools, and the human trials are happening as we speak. Why would you wanted to be injected for a virus that's a 99% cure rate? Stop the 'vaccine' madness! I thought Reason was an intelligent site/magazine but I see I was sadly mistaken. You fools have emptied the pitcher of Kool-Aide. Buh bye.
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