Researchers Used Mosquitos To Deliver Malaria Vaccines
What if mosquitoes could deliver not just the disease but the protection to an infection that kills hundreds of thousands of people annually?

"The mosquito is one of the deadliest animals on the planet," declared two South African researchers in a recent Nature article. This tiny insect is responsible for spreading malaria, a disease that infected nearly 250 million people in 2022 and killed more than 600,000 of them. Most of the victims live in sub-Saharan Africa, with children under 5 years of age accounting for nearly 80 percent of all malaria deaths.
But what if mosquitoes could deliver not just the disease but the protection? In a groundbreaking proof-of-concept clinical trial, researchers in the Netherlands recruited mosquitoes to deliver an antimalaria vaccine with each bite. As The New England Journal of Medicine reported in November, the mosquitoes were infected with attenuated malaria parasites modified to die a week after multiplying in the livers of the trial subjects bitten by the mosquitoes. Allowing the parasites to proliferate briefly in liver cells, the researchers hoped, would induce a strong protective immune system response.
Remarkably, it worked—nearly 90 percent of the subjects later bitten by mosquitoes carrying the natural malaria parasite did not contract the disease. This initial immune response suggests that the protection offered will last longer than current vaccines.
While mosquitoes as vaccine-delivery systems might sound futuristic, the concept has opened a new frontier in malaria prevention. For practical use, the next step is to test and develop an injectable vaccine using the modified parasites. If successful, this could revolutionize how doctors approach mass immunization efforts.
Meanwhile, progress is already being made with more conventional vaccines. After decades of effort, two safe and effective malaria vaccines for children have been approved since 2021. These vaccines reduce clinical malaria cases by more than half in the 12 months following the full administration of four doses. They are particularly effective during the high-transmission rainy season, cutting cases by three-quarters. But frequent booster shots are needed, since protection lasts only about a year.
The World Health Organization projects rapid adoption of these vaccines, with plans to administer 40 million to 60 million doses annually by 2026 and 80 million to 100 million doses annually by 2030. This represents a massive public health campaign in some of the world's poorest countries.
As the fight against malaria continues, the combination of traditional vaccines and innovations such as mosquito-delivered immunizations brings renewed hope to combating one of humanity's oldest and deadliest foes.
This article originally appeared in print under the headline "Malaria Vaccine Delivered Via Mosquito Bite."
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And what happens when nature takes over? How does this effect other animals the mosquitos will prey upon?
I'd rather see them release mosquitos that breed the species into extinction
Why would depopulationists want fewer Africans to die?
DEI.
Well, much of Africa does have excess black people, based on global demographics.
I was told yesterday anything man does is natural, so this is nature taking over according to those experts. What could go wrong?
Just because something is 'natural' doesn't mean there aren't consequences.
I'm not sure what conflict you see with those two things.
A hurricane is natural, but also causes destruction.
A vaccine is natural, but has second or third order consequences that can't always be predicted.
Monkey's are known to use tools, does this make primates 'unnatural'?
Monkeys no. Lizard people yes.
Malaria is natural.
And yet your commentary was so insipid and poorly argued that I can't even recall whether you were arguing for or against the reintroduction of the Red Wolves.
Yes, the species was more memorable than your position.
I'd rather see them release mosquitos that breed the species into extinction
This is between infeasible and wish casting. Assuming you just take a fairly normal mosquito and engineer something to make it sterilizing, you'd have to make them 1:1 for every wild type mosquitoes just to compete... forever. At 10:1 you might be able to win on some sort of reasonable time frame but, again, it would have to be for many protracted years and you'd still be making 10X as many mosquitoes as there were naturally. Altering thing by making some hyperpromiscuous mosquito that sterilizes the wild type might buy you some narrow transient advantages with regard to the competitive ratio but creates it's own disadvantages in that 1:1 assumes your engineered mosquitoes are relatively interchangeable with the wild type but promiscuous, steriliz*ing* mosquitoes are almost certainly going to be themselves more sterile.
Ultimately, it winds up being a much more expensive game of importing Gorillas to kill the Chinese Needle Snakes killing Bolivian Tree Lizards with technology we don't have and which may not exist.
What if the mosquitoes get loose and take over the island? Then years later escape the island?
Life, uh, uh, finds a way.
You're Goldbluming.
So these aren't organic mosquitos?...Pass!
10 Democrats help Republicans advance GOP funding bill to avoid shutdown
https://kfor.com/hill-politics/10-democrats-help-republicans-advance-gop-funding-bill-to-avoid-shutdown/amp/
Last year they called it "bi partisan". Wonder what changed?
A large number of votes?
TDS.
210 Democrats and 1 Republican is bipartisan.
200 Republicans and 10 Democrats is just plain traitorous to our (D)emocracy.
>What if mosquitoes could deliver not just the disease but the protection to an infection that kills hundreds of thousands of people annually?
What if mosquitos could vaccinate against obesity? Wanting to do drugs? Defying authority? What if people are injured?
What if the vaccine isn't as good or safe as claimed? Why would we assume it is?
What part of consent is so hard to understand?
Your betters consented for you. Why else bother having democracy?
The problem comes that Ron Bailey is a degusting sub human faggot.
Anyone that support forcing people to take drugs against their will, and without their knowledge deserves to be shot in the kneecaps then burned alive.
Bailey is an evil entity.
What part of consent is so hard to understand?
One assumes that our 'betters' don't think that dirty poor black people in foreign countries have any agency.
It's the same reason why Black conservatives are openly called 'Uncle Tom's' or 'race traitors' by the American left. In fact, it's one reason why Pluggo is set to ignore. It's just assumed that the natural place of minorities is under the thumb of white progressives who are the only one's capable of making the correct decisions for those dirty poors.
That being said, I can at least concede that sometimes extraordinary measures can be required of extraordinary circumstances, but malaria has been a part of that region so long it's fundamentally altered parts of the human genome that comes from the region. Namely, sickle cell anemia is a straight line between malaria and human blood cells. Thus it's clearly not a new situation, and while this solution is new it's also not the only possible solution either.
I'd be in favor of eradicating malaria, but I'm not so sure this solution would actually do that. Even well intentioned genetic modifications could have unintended negative results. We simply aren't able to model this kind of thing well, and it seems to me that the precautionary principle applies.
"Poor kids are just as bright and just as talented as white kids.”—F. Joe Biden
What part of consent is so hard to understand?
You sound anti-Science.
What if the mosquitoes were part of a CIA op to sterilize Africans funded by USAID and the NIAID by the same researcher who botched the AIDS pandemic and insisted that COVID had to have come from a Chinese wet market?
Dozens reported killed after Trump orders ‘decisive’ strikes against Yemen’s Houthis
https://www.cnn.com/2025/03/15/politics/trump-houthis-military-action/index.html
How do you Peanuts feel about Warmonger Donnie now?
Kudos for not posting a link to child porn this time.
"The US strikes killed at least 31 people and injured 101 others in Yemen, mostly women and children, the Houthi-run health ministry said."
Yeah. And the hospitals will run out of fuel in 12 hours.
I'm sure the middle eastern propagandists aren't lying this time.
How do you soot women... And children?
Easy, you just don't lead 'em so much
Even the barbarians tend to value children, but it's unclear why they would care if women are bombed. I'd presume they are just as upset about women dying as they are buildings being blown up as both of them are property to that culture.
Using the military to secure free trade seems like a legit use. There is a long history of this dating back to Jefferson and the Barbary pirates.
He's trying to conflate it with sending troops, weapons and aircraft to other peoples wars like his political heroes did, to justify arming Ukraine or overthrowing Iraqi, Syrian and Libyan leadership.
They're terrorists. So, I don't care.
"How do you Peanuts feel about Warmonger Donnie now?"
Shooting back against attackers who have physically attacked American shipping outside their territory, isn't warmongering no matter how much you bloodthirsty neocons want to pretend otherwise, Plugly.
Get back to us when Trump sends troops to Syria or conducts a bombing campaign on Libya to assist rebels.
The life and death of a thought-machine. It's a long read, but worth it. Below are excerpts.
https://www.tabletmag.com/feature/rapid-onset-political-enlightenment
The digital and media echo chamber of the left and what they created was probably the most fascist outcome of Obama. Despite having control of social media, most majors news stations, sites like reddit, etc... they still then decided to use their powers for mass censorship. And it was working until Musk decided to buy Twitter. Then it was exposed with the Twitter and Facebook files, knowledge of censorship groups, etc. And despite this knowledge the left rages even more that their power center was exposed and quite frankly defeated.
"Until the fever broke. Today, Donald Trump is victorious, and Obama is the loser."
Maybe. Unless the WEF-progressive block is playing 4D chess, or just truly adept at not wasting a good crisis. With control of media, academia, Hollywood, and the, ahem, deep state, and thus mass public opinion, I can see a astro-turfed counter-revolution in 2028, with establishment of a COVID-era nanny state, but for every aspect of life.
Tin foil bullshit
Erudite as ever shrike.
Stick to child porn and calling everyone nazis.
What about 5-year-old boys dressed as Nazis?
Shrike will allow it.
Mask up shrike!
And your evidence otherwise, Diet Shrike?
Shrike was one of the dumbasses who fell for the digital/media propaganda. No thought of his own. Just does what he thought everyone else was doing. Now he rages that he was tricked and is in denial.
WHAT MAKES IT "Tin foil bullshit", DIET SHRIKE?
Can you point to the wrong bit for us?
Whats funny is the very things discussed in that article are what convinced shrike he was on the 80% side of opinion while he was always on the 20% side. It is why he is still in denial.
That is quite a good article, and does help explain my observation that enormous swathes of people seemed to be going completely insane, in sync.
Jeffsarcs dems have gone fully psychotic. Firebombing tesla. Marching with swastikas. Judges ordering the return of TdA Venezuelan gang members. Assaulting drivers of tesla. Raging at any spending cuts. Demanding Musk be deported. Supporting hamas supporters.
The democrats have completely lost it. No care for society or constitutional order.
I hope they keep it up. Ironic, given the crowd, but these maskless Democrats are the best thing to inoculate the country against their idiocy with.
The judge should be arrested for aiding terrorists, or at the very least be forced to house them in his residence
All political violence in the US has been 100% in one direction.
MAGA aren't the ones shooting up Christian schools, or politicians ballgames and campaign events.
MAGA aren't the ones burning down laundromats, court houses and historic churches, or encouraging the looting of Foot Lockers and Walgreens.
MAGA aren't the guys running teenagers over with their cars for saying they're keen on Biden or running old men over with ATVs for sticking up a Biden sign in their yard.
MAGA aren't the ones running through campuses screaming "death to Jews" or hiring and shipping rioters across the country.
MAGA aren't the ones holding literal book burnings and screaming for the internet to be censored of ideas that they disagree with.
MAGA aren't the ones bribing judges to practice lawfare and ban or imprison their political opponents, or create crazy injunctions to preserve illegal graft and corruption.
And yet the outright fascists here will pretend that somehow MAGA is the authoritarian danger to public order and freedom.
100% safe and effective mutant mosquitos?
Is Moderna involved?
The mosquitos aren't mutant, the malaria they carry is mutated. Not sure how from the article. Attenunated some how. If not done correctly they will just spread malaria like the first live virus polio vaccines that weren't properly made. Maybe they can't make lysine? Still a bad idea.
And what are the odds of being bitten by a vaccine-carrying mosquito rather than a malaria-carrying one?
If the current malaria vaccine requires four shots and is 50% effective, that would be enough for our many resident anti-vaxxers to conclude it doesn't work at all
Erudite as ever shrike. Stick to child porn and calling people nazis.
How do you differentiate the good and bad mosquitos to know which ones are safe to be bitten by? Especially when the "attenuated" parasites die in a week; do all the good mosquitos carry date and time stamps?
If one person in a million had a bad reaction they’d say it’s 100% unsafe.
What if 950,000 people in a million had an unusually negative reaction, shill? What then?
It would have shown up in testing, duh.
By any objective measure, this is a failure.
Given that many people in these areas need to travel a long way to get medication, requiring it four times every single year means that you will have very low compliance for completing the course, and even if fully deployed as recommended, it has a 50% failure rate.
And these are the advertised rates. The numbers are almost certainly tweaked to look better than they are.
So once you mix advertising versus reality and low compliance, I am questioning whether this money wouldn't be better spent on distributing quinine.
Then you have the medical issues already associated with prevelant spike proteins, like with covid vaccines, and the length of time it stays on your system. Getting it 4 times a year with that knowledge exacerbates the issue.
So what are the side effects of this medication. Is something similar happening? T cell exhaustion is also a real thing.
The argument was that they said the covid shot would prevent you from getting it and transmitting it, neither of which is true.
If they are advertising the malaria shot as being 100% effective, but it’s only 50%, then we would be saying it they are lying.
(And even if they weren’t lying about it’s efficacy, they should never have been given blanket legal immunity.)
MAGA goose-stepping toward fascism noticed by PEOPLE magazine?
Donald Trump Invokes Controversial 1700s Wartime Law Used to Justify Japanese Internment Camps
The Alien Enemies Act of 1798 is a widely condemned detainment law designed to be used in the throes of war. Under Trump, it could be applied to target any non-citizen whom he deems a threat
https://people.com/donald-trump-invokes-alien-enemies-act-mass-deportation-plan-11696920
People magazine? You’re such a sad faggot.
Not only that, the law wasn't used to "Justify Japanese Internment Camps" because the Japanese were American citizens. Most were second and third generation. They were not illegal aliens like Venezuelan gang members are.
The Alien Enemies Act
Whenever there is a declared war between the United States and any foreign nation or government, or any invasion or predatory incursion is perpetrated, attempted, or threatened against the territory of the United States by any foreign nation or government, and the President makes public proclamation of the event, all natives, citizens, denizens, or subjects of the hostile nation or government, being of the age of fourteen years and upward ... shall be liable to be apprehended, restrained, secured, and removed as alien enemies"
The whole article is a lie. Roosevelt and the Democrats never used the act to justify because they couldn't. Instead he created Executive Order 9066.
Then:
"In its 1944 decision Korematsu v. United States, the U.S. Supreme Court upheld the constitutionality of the removals under the Due Process Clause of the Fifth Amendment to the United States Constitution. The Court limited its decision to the validity of the exclusion orders, avoiding the issue of the incarceration of U.S. citizens without due process, but ruled on the same day in Ex parte Endo that a loyal citizen could not be detained, which began their release."
Everything about that article was a lie and People magazine knows it, Buttplug knows it, and even Sarc who is crowing over it below, knows it.
I'm shocked sarc hasn't responded.
Democrats did it first and you didn’t complain you hypocrite. That invalidates anything you say and makes anything Trump does ok.
Poor sarc.
Sarc isn't poor. He's a psychotic drunken liar, who didn't give a crap when the Democrats did it, but will shriek bloody murder even if Shrike posts DNC propaganda fretting about what Trump has not done.
Sarckles knows both he a Shrike are being dishonest, but as long as he gets his troll and his precious attention, he doesn't care.
He's principled like that.
FYI, when "the Democrats did it" includes the Japanese internment itself.
Hey, that's their favorite president you are taking about.
Poor Strawcasmic.
Anyone who thinks this is a good idea hasn't watched enough science fiction.
They haven't thought it through either. How do you let only the "good" mosquitos bite you, and how do you ensure they bite you before the "good" short-lived parasites die off and the bad long-lived parasites infect you?
Bailey's supposed to be the science article writer, yet he can't even think of such obvious questions. What a joke.
Bailey's scientific knowledge extend to what soros, gates, and gretta tell him to believe
That seems dangerous. Would it be possible instead to get the mosquitos to deliver some cod liver oil, raw milk, or hydroxychloroquine?
Huh boy. A late night, a late morning, and a Ron Bailey article. Used to like his articles. At least the science was interesting ... I suppose. He went off the rails with COVID. I didn't mind the calls for more testing; more information is always useful, and the CDC/FDA sure botched it. But then he backed the government ineptitude, mask, distancing, mandatory jabs, probably even the school shutdowns for all I remember now. He believes the climate catastrophists too, and I don't think he's written an unbiased useful article since. Certainly none that a libertarian would be proud of.
And here comes an article about the government using mosquitos to "vaccinate" everybody, without permission, without any individualized choice or even knowing it, because we the people are too damned ignorant and stupid to make decisions about ourselves.
This isn't anything like spraying DDT and no one gets a choice; whatever DDT's problems, the worst it does is not a lot worse than building dams or roads. I don't know how DDT spraying worked, but I do remember Jerry Brown spraying paraquat or something, destroying car and house paint, telling people to stay inside, and other disruptions which were probably similar to spraying DDT around. At least people were told how to avoid it.
This? How do you avoid these mosquitos? This isn't something where you stay inside for 24 hours. How long do these mosquitos live? The modified parasites die after one week. Is that all of them, at once, or some kind of half life. Imagine a real vaccine delivered by jab, which no one knows when jabs turn deadly. "Here, take this jab, it's only 3 days old, so your odds of getting the good vaccine are still 90%, and 10% of getting malaria." Or get the 6 day old jab, where you've got a 10% chance of being inoculated and a 90% chance of getting malaria.
And then extend that to "We're releasing all these mosquitos. They will inoculate 99% of the people they bite on the first day, and the other 1% will get malaria. So come outside and let the mosquitos bite you. By the 4th day, it's 50-50 whether you get inoculated or malaria, but still, come on outside. By the 7th day, it's 99% malaria and 1% inoculation. Remember, you were probably inoculated on the first day, so you are probably safe after that."
And Bailey wonders why people don't trust government "scientists". No wonder I don't trust his articles any more.
And all this by government action, probably taken in secret since we're talking Africa here. Not a shred of objection about individual choice, not a single hint of libertarian principles?
No thanks, Bailey. You're neither scientific nor libertarian.
Bailey was always a hack, I thought he use to be better, but I looked at older articles, and 90% of his linked sources (something he doesn't even pretend to do anymore) were to other stories he wrote.
Much agreed, +1.
Bailey went off the rails way before COVID. Climate change broke his mind years and years ago.
There's a reason he no longer comes into the comments, which is something he did regularly once upon a time.
He repeatedly got railed in the comments and used appeal to authority rather than engaging in the logic of what was being said. It was at least funny to see him in the comments.
school shutdowns for all I remember now. He believes the climate catastrophists too
COVID retardation had some value. There are a number of left-of-center people I follow who used to be in the climate change bandwagon, and post covid have now declared they don't believe in it any more because of the 1:1 venn diagram overlap between COVID alarmism and climate alarmism.
He went off the rails with COVID. I didn't mind the calls for more testing; more information is always useful, and the CDC/FDA sure botched it.
[Tilts hand] The CDC/FDA didn't do well but Bailey was cheering for 40-cycle PCR, 30%-error-rate, shitty bespoke LDTs before that.
I've done the LDT and clinical chemistry thing. I've been the one guy in the lab that can run the test and get the controls to work every time. I've also been the guy that runs 1000 patient samples through the analyzer to conduct 30,000 tests in a single day. The two are not the same. It's like expecting every Uber driver to be an F1 racer and expecting every airline pilot to have graduated from Top Gun.
The judge who just blocked the deportation of Venezuelan gang members has an interesting past including approving FISA warrants on trumps campaign.
https://www.zerohedge.com/political/shady-fisa-ray-epps-j6-tump-judge-preemptively-blocks-admin-deporting-alleged-tren-de
Well imagine that.
Trump’s New World Order Tests the Dollar
Investors are more optimistic about Europe while tariffs cloud the U.S. outlook
...
Many on Wall Street, however, fear the downside of such changes. A weaker dollar would make imports more expensive, boosting inflation and making it harder for the Federal Reserve to cut interest rates. Outflows from U.S. assets that depress the dollar could also drive down stock prices and lead to higher U.S. borrowing costs.
https://www.wsj.com/finance/currencies/trump-trade-tariffs-us-dollar-value-814cbe37
Trump shitting on King Dollar = bad for America.
Investors leaving for Europe.
The Canadian dollar is currently trading at a near historic low of .69 cents USD. Twelve years ago it was $1.01 USD.
Everything you post is retarded and wrong.
WHO should make breeding vegan mosquitoes Job One, and making them into Mosqui-Tofu Job Two.
You can't use the bugs for disease prevention. What will the globalists and environmentalists have left to eat?
What if mosquitoes could deliver not just the disease but the protection to an infection that kills hundreds of thousands of people annually?
*looks around, wonders if anyone thought of the obvious*
Because it would violate the tenets of informed consent, for fuck sakes.
Am I the only one who hasn't lost his fucking mind around here?
No, there's three of four of us.
There are dozens of us. Dozens!
""Because it would violate the tenets of informed consent, for fuck sakes.""
Like fluoride in water.
As the fight against malaria continues, the combination of traditional vaccines and innovations such as mosquito-delivered immunizations brings renewed hope to combating one of humanity's oldest and deadliest foes.
This is tech-bro scientism retardation cranked up to eleven, dosed with meth, red bull and weed.
This attitude is completely based on the idea that:
Technology always works.
Mistakes are never made.
Experts always do the right thing.
That which purports to improve conditions will actually improve conditions.
And probably about 27 more that I haven't thought of.
tech-bro scientism
There used to be a jab at crypto about how the people who needed the freedom and prosperity it promised the most need far more basic infrastructure first. "We set up the Wi-Fi so you can access the consensus network to make and accept payments anywhere along your daily miles-long journey to get fresh water. You're welcome."
Reduces infection by half after 4 doses and the protection only lasts a year. That's not good. Not good at all.
Before we look at doing nebulous evil overlord tactics that override any chance of consent, we should probably work on improving the base medication more.
Mosquito control could also be greatly improved in many places.
Point. Malaria was removed from most areas through universal adoption of windows. If your average mosquito bites only one person in her lifetime, then the malaria rate falls off to nothing.
So attacking the known vector through proven means might be the better solution.
Or, as I mentioned earlier, distributing the treatments that have been known and proven for over a century now.
So sorry that this is happening to you Sarc, Jeff, Tony, SRG, Plugly. Thoughts and prayers in this difficult time.
Democrats hit rock bottom as internal numbers reveal total collapse
Still polling better than shrike, sarc, Jeff, and Tony.
First they came for the pollsters.
“There’s nothing conservative about an unelected South African nepo baby firing people at the VA” Tim Walz says at town hall in Des Moines.
Man, after years of decrying it, they sure turned to xenophobia quick didn't they?
And this valor-stealing imbecile calling Musk a "nepo baby" is insane. He grew up middle class and started his first company from nothing (which would later be sold for $300 million).
Like 83% of all African Americans musks dad abandoned him
Cold.
I mean, I laughed. But, still, if I was in public and heard the comment I'd look over my shoulder to know if anyone was watching so I should pretend to feel guilty about laughing.
Man, we really dodged a bullet in November. Walz may actually be dumber than Kamala.
Man, Tim Walz telling me what it is to be conservative is like those feminists in the toxic masculinity days telling me what it is to be a man.
I've said it before, folks like that explaining conservatism is like a teenage boy explaining menstruation. He may have read about it or had someone tell him something, but he doesn't understand it and has no personal experience with it at all.
"This initial immune response suggests that the protection offered will last longer than current vaccines."
Which is Ron's way of saying attenuated malaria parasite vaccines are already around.
So why not add them to the diseases on the voluntary childhood vaccination list, since a half million kids a year are dying of malaria, which is more than covid killed
Because malaria is a parasite and vaccines against parasites are terrible and ineffective. It just doesn't work. Read forward a few paragraphs. While a vaccine against most viruses can be for life, or at least decades, the Malaria vaccine increasingly decreases in effectiveness over a single year.
The idea behind this is to constantly re-infect people with the vaccine. It's not a stupid idea if you don't care about consent.
Decades of published , and debated research support Ron's assertion that "This initial immune response suggests that the protection offered will last longer than current vaccines."
Correct me if I'm wrong , but is it true that you have published nothing in support of your assertion that "vaccines against parasites are terrible and ineffective" ?
Are you seriously trying to argue basing on an authority that explicitly disagrees with your position?
There is no interpretation where 50% resistance over a course of a year is "effective".
If you're going to go with an "I'm smarter than you" sophistry, you might want to read the article you are discussing.
"controlled human malaria infection at our center"
I don't suppose anyone else noticed that this proof-of-concept experiment on live human volunteers, licensed and approved by the Dutch government, caused actual malaria infections in one out of ten test subjects? I thought not.
""What if mosquitoes could deliver not just the disease but the protection to an infection that kills hundreds of thousands of people annually?""
I would kill them anyway.
Better idea: Bring back DDT and eradicate these things.