Reason Roundup

Ketamine-Based Antidepressant Nasal Spray Gets FDA Greenlight: Reason Roundup

Plus: Trump backtracks on Syria and the NSA promotes its cellphone charging services.

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BSIP/Newscom

The U.S. Food and Drug Administration just approved a depression treatment derived from ketamine. A surgical anaesthetic turned party drug, ketamine has been enjoying a comeback this decade as an off-label treatment for clinically depressed patients who don't respond to other therapies.

Esketamine, a product recently approved by the FDA, is the first antidepressant "in decades to work in a completely new way in the brain," reports the Washington Post. "Older antidepressants target the neurotransmitters serotonin, norepinephrine or dopamine. Esketamine affects the receptor for a different brain chemical called glutamate." More:

The spray acts within hours, rather than weeks or months as is typical for current antidepressants, and could offer a lifeline to about 5 million people in the United States with major depressive disorder who haven't been helped by current treatments. That accounts for about one in three people with depression. […] Esketamine must be administered under medical supervision and can only be used in a certified doctor's office or clinic, according to the conditions of the FDA approval. It is to be taken with an oral antidepressant.

Studies of ketamine-derived antidepressant treatments have been going on now for more than two decades, with the first study published in 2000. "Several studies now provide evidence of ketamine hydrochloride's ability to produce rapid and robust antidepressant effects in patients with mood and anxiety disorders that were previously resistant to treatment," noted an array of scientists in JAMA Psychiatry back in 2017.

An FDA advisory committee voted in February to recommend approval of Esketamine, with only two members of the committee voting no despite having more mixed evidence than with many previous antidepressants.

QUICK HITS

  • The NSA is getting a little blatant, no?

twitter.com/NSAGov

  • Trump again supports some troops in Syria. President Donald Trump may agree with Congress that the U.S. should keep "a small peacekeeping group of about 200" troops in Syria, despite the president's previous promises of total withdrawal. "The White House announcement of a residual force apparently misstated the total—military officials have described plans for a force of about 400—and did not specify its mission or duration," reports the Washington Post.
  • Protecting and serving. The feds will look into last year's killing of Stephon Clark by Sacramento police officers Terrence Mercadal and Jared Robinet, "who fired on Stephon Clark 20 times after mistaking his cellphone for a gun. Clark was struck at least seven times and died at the scene, later determined to be his grandmother's backyard," notes the Los Angeles Times. The local district attorney's office announced on Saturday that it would not file charges.
  • Arpaio 2.0 falls out of conservative favor. The enduringly awful former Milwaukee County Sheriff David Clarke has been banned from Fox News and dumped by the super-PAC he previously served as the face of, according to The Daily Beast. Find Reason coverage of Clarke's history here.
  • A free-market economist gloats. "In 2009, the U.S. unemployment rate exceeded Europe's for the first time in decades. Apologists for European labor market regulation rejoiced, so I publicly bet that European unemployment would exceed U.S. unemployment over the next decade," writes Bryan Caplan at the Library of Economics and Liberty. "Ten years later, the bet's results are now in. The average U.S. unemployment rate during this decade was 6.8%. The EU-19 (the original EU-15 plus the Baltics and Slovakia) was 10.3%. … What does this all mean? To me, this bet is just a small extra piece of evidence in favor of the orthodox and blindingly obvious theory that Europe has higher unemployment than the U.S. because it has stricter labor market regulation. Flexible labor markets respond more sharply to shocks, but yield lower unemployment rates overall."
  • Jonah Goldberg on CPAC as "pseudo-event." The president's two-hour speech capped off the infomercial-meets-mega-church-meets-comic-con vibe. It "was a virtuoso performance," writes Goldberg. "But the overriding theme to the pudding was that there is only Trump….In Trump's sprawling address, which he began by literally hugging the American flag, he denounced and castigated any competing source of conservative authority, including several people who served in his own administration."
  • Tune in to spark joy:

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108 responses to “Ketamine-Based Antidepressant Nasal Spray Gets FDA Greenlight: Reason Roundup

  1. The NSA is getting a little blatant, no?

    Can’t snoop on calls anymore, but still need that fix.

    1. “Not today, ISIS.”

  2. President Donald Trump may agree with Congress that the U.S. should keep “a small peacekeeping group of about 200” troops in Syria…

    He wants his own Blackhawk Down movie.

    1. Or he wants to avoid his own “13 Hours” movie

  3. The U.S. Food and Drug Administration just approved a depression treatment derived from ketamine.

    And not a moment too soon with the Momo lurking about.

  4. The feds will look into last year’s killing of Stephon Clark by Sacramento police officers Terrence Mercadal and Jared Robinet, “who fired on Stephon Clark 20 times after mistaking his cellphone for a gun.

    Will the feds also arrest protestors when they find nothing they deem worth prosecuting?

    1. They *could* mistake a protest sign for an assault weapon.

  5. The president’s two-hour speech capped off the infomercial-meets-mega-church-meets-comic-con vibe.

    Well, Nick Gillespie was duly impressed.

    1. Nick, being an anarchist rather than a simple never Trumper, still has the ability to see humor and entertainment when it is presented. Conservative elites, like all other elites, love to turn up their noses at anything low brow, because if you can’t do that then their journalism degrees aren’t worth anything

      1. What is this new “Nick is an anarchist” meme? Didn’t LC89 start that foolishness? Describing Nick as a minarchist might be giving him too much credit, let alone anarchist.

      2. Nick is not an anarchist.

        1. What is he then?

          1. I’ll take back my statement about anarchy, it’s not important. All I’m saying is Nick pulls himself back from the fray in an attempt to tell it like it is. I hate his both sides-ing to the Nth degree, but his coverage of CPAC seemed well thought out and done the right way.

          2. What is he then?

            A ‘liberaltarian’. A leftist, though he still possesses enough shame to try and cloak his progressivism in the skin of the jacket his toxic statism killed lo these many years.

  6. The average U.S. unemployment rate during this decade was 6.8%. The EU-19 (the original EU-15 plus the Baltics and Slovakia) was 10.3%

    Serious question: Does the EU calculate their unemployment using the same bullshit methodology as the USA?

  7. Listen…. I know he said he would pull our troops, which I am happy to see…. but in a country of 18 million people, are we really going to argue semantics about 200 troops?

    Seems a bit pedantic

    1. That’s right. Keep lowering the standards for Trump.

      1. You thought he would cause WW3, so what about your standards? You must wake up every day super pissed he is pulling out of illegal wars.

        And don’t you have rapists to defend? Our oppressive government is preventing hard working murderers and rapists from crossing the border, and here you are arguing with me.

        1. So, instead of addressing your lowering of your standards for Trump, you pull a whataboutism and then attack me with a lying slander. Sounds typical.

          I mean, if you are just going to say that you will say or do whatever in order to shill for Trump, that would at least be more honest.

          But if you’re not a total shill, then explain why Trump should receive the benefit of the doubt here when “pulling out of Syria” really isn’t pulling out of Syria.

          1. Going from 2,000 troops to 200 is an improvement.

            But it begs the question: how can Trump, as CinC, have legitimate authority to alter troop levels – which involves spending – without the explicit assignment of those funds by Congress… but not have legitimate authority, as CinC, to build defensive fortifications on the US/Mexico border?
            If it’s the amount of money concerned, then we’re totally out of the realm of principles.
            C’mon libertarians – where’s all your shouting about the tyrannical presidency here?
            Where’s Congress passing a resolution to stop Trump here?

          2. “pulling out of Syria” really isn’t pulling out of Syria.

            As opposed to sending in the troops in the first place and not managing to close the Gitmo torture farm in 8 years? The standards are already low. When you compare to the blatant bullshit of prior presidents, Trump is looking pretty good.

            And you never addressed Ryan’s point which was that it is pedantic to not consider a draw down to 200 troops a withdrawal. There are at least 275 personnel guarding the embassy in Baghdad.

            But, by all means, keep up the TDS you disingenuous twat!

          3. I get it, less war is more war… Live your truth Jeff.

            He surpassed my standards when he started pulling out of multiple war zones. Now back to you, hows your vision of WW3 looking?

    2. Eisenhower had 100 advisors in Vietnam,after it was all over the dems blamed him for starting that war.

  8. The NSA is getting a little blatant, no?

    Do they still give away colorful juggling blocks at the trade shows? That was *so* nice!

    1. Now you get a free Echo Dot.

      1. Bazinga!

  9. The Coffin Business Is Booming in Central America Due to Gang Violence

    The solution is obvious ? allow anyone from Central America to move to the United States.

    #AbolishICE
    #NoBanNoWall
    #OpenBorders

    1. I read that as “coffee” business and thought it meant people were drinking deep to stay alert.

      1. Way down among Brazilians
        Coffee beans grow by the billions
        So they’ve got to find those extra cups to fill!
        They’ve got an awful lot of coffee in Brazil!

    2. They’ll bring food trucks AND strengthen the mortuary industry?! Move over dead opiod addicts, we got dead gang violence victims to process.

      Who said democrats don’t create jobs?

  10. President Donald Trump may agree with Congress that the U.S. should keep “a small peacekeeping group of about 200”

    Otherwise known as bait.

    1. Cue “Trump is a master baiter” jokes….

  11. A surgical anaesthetic-turned-party drug, ketamine has been enjoying a comeback this decade as an off-label treatment for clinically depressed patients who don’t respond to other therapies.

    According to my number one source for technical knowledge – the movie Armageddon – ketamine is a horse tranquilizer.

    1. When all else fails, knock yourself out for a few hours.

    2. Your ability to suspend disbelief has Stockholm Syndrome from that movie’s mental abuse.

      1. Third greatest movie of all time and the crown jewel of that golden age of cinema known as the late 90’s.

        1. I enjoy the movie overall , but my engineer mind gets very cross at it.

        2. That movie was the greatest example of Bay’s post-modernist schtick. Just throw as many tropes as you can into one movie, plot be damned. And I have to say, it worked. There was nothing remotely believable from that movie- from the character motivations to the science to the logic they repeatedly used. Every single moment of tension was completely made up- “Oh noes an asteroid storm; giant valley to jump over; crazy military guy, crazy buchemie; gas pocket; detonator malfunction.”

          And yet it all worked when strung together because of gorgeous cinematography, and Liv Tyler’s pouty lips. One of the best saturday afternoon guilty pleasures in history.

    3. According to my number one source for technical knowledge – the movie Armageddon – ketamine is a horse tranquilizer.

      There was a narrow window in the early 90s between rave and grunge culture where ketamine was popular. Pharmacies didn’t generally stock it and large-animal veterinarians tended to have pounds of the stuff behind 1-2 measly padlocked doors, miles and miles away from any police station.

      Then vets got wise and everybody figured out that you could cook meth at home.

  12. Glad to see y’all mentioning Heaton. He is your better.

  13. To me, this bet is just a small extra piece of evidence in favor of the orthodox and blindingly obvious theory that Europe has higher unemployment than the U.S. because it has stricter labor market regulation. Flexible labor markets respond more sharply to shocks, but yield lower unemployment rates overall.

    *golf clap*

  14. So if I plug in my phone at the NSA charging station, and I am an AT&T customer, does that mean the NSA steals my phone info twice? Asking for an AT&T customer.

    1. No, they just steal it faster.

      1. You don’t think they clone you phone, while you have it plugged in? Have you not seen the documentary series, “Person of Interest”?

  15. Michael Bloomberg will not run for president in 2020. The billionaire will instead help fund an effort to elect Democrats.

    Another issue where I disagree with my progressive friends. Most of them want to “get money out of politics.” They fail to realize that billionaires are usually on their side on issues like immigration and gun safety.

    Good for Bloomberg.

    #LibertariansForBloomberg

    1. fund an effort to elect Democrats

      , whatever that means. #DraftHillary?

      1. My understanding is that Hillary Clinton will not run again. Of course if she does run, she immediately becomes my first choice.

        1. She’s still Muellering it over, OBL.

    2. It’s like reading Joseph Heller every day.

      1. The only “Heller” I know of is a terrible Supreme Court decision I’d like to see overturned.

  16. The Lich Queen is still coming for your soul:

    Has Hillary changed her mind? Clinton now says she is ‘surprised her announcement NOT to run in 2020 was taken at face value and is waiting for the Mueller report before making a final decision’, sources claim

    Damn, this woman’s thirst for power rivals Caesar. Also, this was a bit confusing, but it could just be a Daily Fail SOP fuck-up:

    ‘The person also says she is extremely unlikely to run, but that she remains bothered that she’s expected to close the door on it when, say, John Kerry isn’t.

    Did they mean Bernie? I don’t think Kerry’s a candidate for anything other than living off his wife’s trust fund right now.

    1. she remains bothered that she’s expected to close the door on it

      *Hot* and bothered!

    2. Please oh please don’t go away.

      1. I hope she keeps picking at the “rule of law” scab until it bleeds, if you catch my drift.

    3. “They cannot get rid of me that easily.”

      Somebody throw another bucket of water on her, please.

    4. Licht queen – only magic or silver weapons will defeat her.

      This dovetails nicely with the article someone posted yesterday about people in hospice who are tying to hold on until the Mueller report is released before their porch light goes out.

    5. “Crawl Hillary Crawl” 2020 bumper sticker.

    6. She was hoping for a huge chorus to rise up begging her to run.

    7. Clinton now says she is ‘surprised her announcement NOT to run in 2020 was taken at face value and is waiting for the Mueller report before making a final decision’

      I haven’t taken anything she’s said at face value since 1992. I just don’t care.

  17. Federal deficit up 77 percent so far this budget year

    WASHINGTON ? The federal government recorded a budget surplus in January. But so far this budget year, the total deficit is 77 percent higher than the same period a year ago.

    The Treasury Department said Tuesday that the deficit for the first four months of this budget year, which began Oct. 1, totaled $310.3 billion. That’s up from a deficit of $175.7 billion in the same period a year ago. The surplus in January was $8.7 billion. NBC News

    WINNING!

    1. This is Shrike, right?

      1. #MoneyshotIsTheNewPalinsButtplug

      2. Yeah, it’s the hicklib pederast that posted kiddie porn links and got himself banned.

        1. Liar.

          A true Trump-tard you are.

          1. So, what’s your version of the story?

            1. There is no story.

              I logged in one day and my old screen name didn’t work.

              1. I logged in one day and my old screen name didn’t work.

                Sure, Eichenwald.

              2. So you got banned, and came back despite Reason asking you to leave because you posted kiddie porn links.

          2. Ass-blasted hicklib lies about posting kiddie porn links.

  18. How bad is it in Venezuela? Is it getting better or worse?

    Stat of the day:

    “A 2 million percent inflation rate is ravaging savings and salaries, devastating a once-vibrant manufacturing sector by suppressing demand.”

    http://www.wsj.com/articles/hy…..551798001?

    That 2,000,000% inflation rate is up from 833,000% in October and 488,000% in September.

    http://www.wsj.com/articles/ve…..541634089?

    This is when things like the International Criminal Court probably get in the way. There isn’t any way out of this for Maduro. If France could offer Maduro and his family asylum, and let him take some of his money with him, Venezuela might avoid a tremendous amount of suffering and bloodshed. Spending the rest of his life on the French Riviera is a hell of a lot better than any of his other options now, but I don’t think that kind of option is on the table with the ICC anymore.

    1. Spending the rest of his life on the French Riviera is a hell of a lot better than any of his other options now

      I would really hate for his constituents not to get to say goodbye like the adoring crowds that sent Gadaffi and Mussolini on their way.

      1. But what will keep the Castro regime propped up in Cuba?

  19. So David Clarke has gone too crazy even for Fox? Wow.

    1. actually it sounds like all he did was ask to be paid and they said no.

      1. Chemleft is too busy importing rapists to read anything other than clickbait headlines which he fully buys into every time.

  20. Court Rules Father Cannot Halt Daughter’s Transgender Hormones?or Even Call Her a Girl
    Last Wednesday, the Supreme Court of British Columbia (B.C.) ruled that a 14-year-old girl may undergo transgender hormone “treatments” to support her transgender identity as a boy ? without her father’s consent. The court went so far as to threaten to penalize the father’s speech. If he calls his daughter a girl, that would constitute “family violence,” which would be punishable by law.

    1. It’s a Brave New World up north.

      1. Giving absolute authority to make irreversible physical changes to minors for what may be quackery.

    2. the Supreme Court of British Columbia (B.C.) ruled that a 14-year-old girl may undergo transgender hormone “treatments” to support her transgender identity as a boy ? without her father’s consent.

      And without her father’s money, right? RIGHT?!

      1. Of course, it’s Canada. They aren’t barbarians. They have universal health care.

    3. You don’t think you are really responsible for your child’s welfare, do you?

    4. I simply don’t understand how a court can determine that a child cannot give consent to have sex but can give consent to change their sex. The cognitive dissonance is…

      Wow. This is really fucked up.


      1. Good point

      2. I simply don’t understand how a court can determine that a child cannot give consent to get a tattoo but can give consent to change their sex. The cognitive dissonance is…

        Wow. This is really fucked up.

        I simply don’t understand how a court can determine that a child cannot give consent to get a job but can give consent to change their sex. The cognitive dissonance is…

        Wow. This is really fucked up.

        I simply don’t understand how a court can determine that a child cannot give consent to get any other type of surgery but can give consent to change their sex. The cognitive dissonance is…

        Wow. This is really fucked up.

  21. “Delighted to have @kmanguward on the show today to talk about how @MarieKondo offers a worldview alternative to the likes of Tucker Carlson and Bernie Sanders!”

    I’m glad to hear KMW will be on with Heaton, but, for a second there, I thought we would be treated to hearing Kondo on the show to talk about Carlson and Sanders, which would be like having Mother Theresa on to talk about Stormy Daniels and Melania.

  22. Gun-grabber governor BTFO :

    TAOS ? In a 3-2 vote Tuesday, the Taos County Commission passed a resolution opposing firearms legislation that some believe would violate residents’ constitutional rights and unfairly target law-abiding gun owners.

    The move made Taos County the 26th out of 33 counties in the state to adopt the so-called Second Amendment sanctuary resolution.

    Over 80 percent of Taos County went for Lujan-Grisham in the last election. Colfax County pulled back their resolution because the language resisting these laws weren’t strong enough and are expected to pass one in the next few days. Edgewood, just east of Albuquerque, is about to tell Santa Fe county to go fuck itself and be a 2nd Amendment Sanctuary City.

    1. The best part is that the commie shitheels in the Roundhouse remain their perpetual condescending and antagonistic selves:

      Egolf calls the behavior of sheriff’s across the state ‘unprecedented’ and says even though most of the counties are against the bill, most of the state is actually for it.

      “Well, it might be tense for the 15 percent of the state or so that doesn’t want universal background checks, but they’re very popular. 85 percent of people in the state support background checks,” said Egolf.

      1. 85 percent of people in the state support background checks

        So?

  23. “Ketamine-Based Antidepressant Nasal Spray Gets FDA Greenlight”

    And what a pretty Greenlight it is…

    1. https://www.huffpost.com/entry /joe-biden-2020_n_5c796502e4b087c2f295ba31

      Fuck HTML

  24. The Commerce Department said Wednesday that — despite more than two years of President Trump’s “America First” policies — the United States last year posted a $891.2 billion merchandise trade deficit, the largest in the nation’s 243-year history.

    The trade gap with China also hit a record $419 billion, underscoring the stakes for the president’s bid to reach a deal with Chinese President Xi Jinping as soon as this month.

    The department’s final 2018 trade report, which was delayed by the government shutdown, showed that the U.S. bought far more in foreign goods than it sold to customers in Europe, Asia, North America and Africa. The goods shortfall topped the 2006 record of $838.3 billion, set as the housing bubble was peaking, and marked the third consecutive year of rising deficits. wapo

    MASTER DEAL MAN!

    1. Shriek loves defict and kiddie porn.

      1. And disrespecting Reasons’s property rights after they banned him.

  25. “U.S. employers need to enhance the skills of their current and future workers for the economy to remain on its robust growth trajectory, said Ivanka Trump, ahead of a meeting Wednesday with prominent business executives, educators and governors.”

    http://www.wsj.com/articles/iv…..551881026?

    Thank God Ivanka is there to tell business executives, educators, and governors what we need to do for the economy. How would they know what to do otherwise?

    Ivanka 2024!

    1. What’s the point of this story? What is a rational person supposed to learn from it?

      1. Oh sure. Nick mocks every member of the Trump bloodline for no reason (*drink*) at all and it’s called libertarianism. Ken mocks one of them once and, all of the sudden, $park? is gonna swoop in and defend her from pointless criticism? How… chivalrous of you.

    2. So they need to teach their workers to learn to code?

  26. Ketamine nasal spray? Convenient.

  27. Normally the Feds should stay out of basically everything. But I’m all for them prosecuting dirty/incompetent cops when the state fails to do so.

  28. Start working at home with Google! It’s by-far the best job I’ve had. Last Wednesday I got a brand new BMW since getting a check for $6474 this – 4 weeks past. I began this 8-months ago and immediately was bringing home at least $77 per hour. I work through this link, go to tech tab for work detail.. http://www.Home.jobs89.com

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