The first patient diagnosed with Ebola in the US, Eric Duncan, has died, a Texas hospital says.
Thomas Eric Duncan, who caught the virus in his native Liberia, was being kept in isolation in a Dallas hospital and receiving experimental drugs.
Earlier the US announced new security procedures at entry points to check travellers for symptoms of the virus.
More than 3,000 people have died and 7,500 infected, mostly in West Africa, in the worst Ebola outbreak yet.
"It is with profound sadness and heartfelt disappointment that we must inform you of the death of Thomas Eric Duncan this morning at 7:51 am," a spokesman said in a statement.