Pot Genome Sequenced
Here's a bit of good news - some researchers at a start-up biotech company have sequenced the genome of the marijuana plant. As Bloomberg reports:
Kevin McKernan was leading Life Technologies Corp. (LIFE)'s Ion Torrent DNA-sequencing research when a new business opportunity caught his eye: marijuana.
A year later, McKernan, 38, has quit his job, formed a startup run from his house in Marblehead, Massachusetts, and announced today that the company had sequenced the entire genome of the cannabis plant.
The project, which cost about $200,000, may lead to the development of treatments for cancer, pain and inflammatory diseases, he said. McKernan's company,Medicinal Genomics, is making the data public using Amazon.com Inc. (AMZN)'s EC2 cloud- computing system. McKernan called the work a "draft assembly," and it hasn't yet been published in a peer-reviewed academic journal.
McKiernan says that the new genomic information can be used to produce novel pharmaceuticals. Well, certainly that's a good idea. But since the sequence is open-access, perhaps some breeders in Mendocino might find a use for this information, too. Munchie-free weed, anyone?
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maybe shorten the testable half-life.
This is the first step of The Corporashunz taking over. Fast forward 10 years: My weed will be legal but the equivalent of a joint will cost me $50.
FUCK you, Corporate America.
sweet. Now just cross it with Kudzu and release it into the wild.
can we work some tomato or another berry in there too?
That is the best idea I've heard in a good long while.
Dude, have you never smoked ditch weed? My buddy found some once in Oklahoma in college. Takes a shit ton to get you high, though.
The genetic modifications will rectify that shortcoming.
that was probably the male plant.
I don't know, but I been told - if you're not selecting for psychological effects, it will revert to low-THC hemp fairly quickly in the wild.
That's to protect itself from hippies.
That's to protect itself from hippies.
Now just cross it with Kudzu and release it into the wild.
Can you imagine how much money the federal gov't would spend to eradicate your kudzu-pot? Our current debt would be lost in the noise.
sadly i could see the plan backfiring in this way.
Complete scorched earth policy for all ground not covered by Federal Crop Permits. Lawns and Gardens included.
Cross it with mint to increase the flavor but still keep the invasive encroachiness.
KNOCK, KNOCK, KNOCK!
**Shoots office dog**
This^^
"Munchie-free weed, anyone?"
Heretic!
The nerve of this guy!!! Doesn't he know THERE IS NO MEDICINAL USE OF MARIJUANA!!!!!!!!!!
He's out there doing God's work in some of America's toughest neighborhoods.
The mean streets of Marblehead.
They ought to splice the MJ genes into all other plant species, then all life will be illegal!!!!!! Damn it!!!!!!!!!!!!!!
I believe that the FDA is already working on making everything illegal.
Everything ought to be illegal, or at the very least regulated.
Why not both?! Two great, bootlike, tastes that taste great together!
Relax, all right? My old man is a genome sequencer, he's got this ultimate set of electrophoresis gels. I can fix it.
This gene map is a little more difficult to follow than most. It kind of meanders around, seemingly losing its track in places, until it finally winds up mellowing out on the curb in front of a 7-Eleven.
Thanks, you made my day.
Partially correct, the sequence isn't assembled yet. This was done de novo on illumina, a next gen platform with lots of short reads, which will make assembly more computationally intensive.
I can't wait till people start freaking out over GM pot.
Didn't that show up in some recent DEA propaganda?
It's high time they sequenced the marijuana genome. It makes so much sensimilla to do this instead of wasted time pottering around.
Go to your room.
I'd imagine the first "private sector" use would be developing mj that does not produce the metabolites that drug screens test for.
The structure of THC is pretty simple so if you change it there's a good chance it won't get you high any more. So I think we are stuck with the metabolites and the drug test. This is good since we still want to be able to see if someone who killed someone with their car was high on pot or ethanol or whatever.
Knowing the genome, in this case, may still not tell you which one or more particular genes produce THC. THC is not a protein coded for by a single gene but a small molecule probably synthesized in several steps by several enzymes, each coded for by a different gene. There might be as many as 10-20 genes involved or as few as 2-3. Just my edumacated guess.
THC is not the only thing in pot that gets you high, though.
There's a recent book by Rosenthal with some pretty cool gas chromatography/mass spectromety graphs for different strains. He also mentions the non-cannabinoid chemicals present to varying degrees and how they influence the high.
Goddamn you, LIBERTARIAN CHEMISTRY NERDS.
Goddamn you, LIBERTARIAN CHEMISTRY NERDS.
Are the metabolites in your system only as long as you're high, though? Can you tell if they were actually high at the time of the accident or if they merely smoked before bed last night and in an unrelated incident killed someone with their car today?
That is the problem with the metabolite tests. Metabolites are in your system long after you swallowed the last cheetoh. I have heard the reason is that the metabolites are fat soluble and so they take much longer (weeks) to flush out of your system.
I believe the system is much more Orwellian than that right now--at least in my state. I have a friend who is a counselor at a women's prison; one of the inmates is there because she tested positive for MJ a few days after another driver crossed two lanes of traffic and ploughed into her car. Since there was fatality, the MJ-using woman was tried and convicted of (I think) vehicular manslaughter.
Your drug war at work!
This is good since we still want to be able to see if someone who killed someone with their car was high on pot or ethanol or whatever.
Why should we care, exactly, if the deadly driver was high, or drunk, or messing around with his stereo?
So we can punish the sinning as well as the irresponsible behavior, duh.
Isn't that what K2, etal., basically are? Cannabinoids that can't be tested for?
that can't be aren't tested for yet
ftfy.
I'm surprised it took this long. I would have expected it be, like, the second or third thing sequenced.
they were gonna do it first, but like, stuff happened and they kinda forgot about it for a while.
I see where this is going. By the time it becomes legal you'll have to pay Monsanto a royalty to smoke a joint.
and growing your own will be impossible without a USB dongle.
by making the genome open source, I think this guy precluded Monsanto, or anybody else, from patenting it. I could be wrong, I am not a lawyer, I did not go to Harvard, etc.
"Pot" genome? That's a little vague. Was it kush? Sour deisel? Afgooey? Hemp?? More info please!
who comes up w these weird names?
Rumor has it that a particularly strong batch came through town this summer known as "Mike Tyson". (I'm not too sure I'd wanna tell Big Mike he had a "wierd" name, if you know what I mean.)
Mike Tyson always was overrated and not only that he's 45 now and lost 120 lbs. You could probably kick his ass these days.
Since the names will remain total bullshit until there's a whole catalog of genomes to tie the names to, what does it matter?
(even then the catalog is gonna be pretty unspecific. "Cannabis Genome #427, 20 samples sequenced. Samples identified under 15 different names, but all identical.")
Well, I'm curious if it the genome that produced the magnificent specimen in the picture, or is it the rope grade weed the Founders grew?
See my post above regarding GCMS plots in a recent Rosenthal book. He's got em for several big strains showing some of the differences in chemical makeup.
yeah, the gas chromo is interesting information, but it still doesn't actually peg a strain to any particular genetics.
but "Alaskan Thunder Fuck" is and awesome name.
The War on Drugs filters everything. I read that as Pot Genome Sentenced.
Looks like some pretty good bud to me dude.
http://www.total-anon.at.tc
Dude.
Duuuuuuuuuuuuuude
This is heinous. I'm you libertarians with polluting the genome of this sacred, ancient, medicinal healing plant with genes from cows or fish, but I can assure you the hemp products that we sell in our collective will be 100% GMO free. And we won't be happy if someone's GMO mutant frankenweed pollutes our crop either.
See my post above regarding GCMS plots in a recent Rosenthal book. He's got em for several big strains showing some of the differences in chemical makeup.
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thanks
thanks