A piece in Fortune touts Modafinil, an anti-narcolepsy drug used "off label" to keep people awake, alert, and hyperfocused, but without the side effects of caffeine or Ritalin or the addictive potential of amphetamines. A friend of mine who's tried it claims that it lives up to the hype. My only concern is that it sounds too good to be true: I can't help but suspect we'll all eventually start losing our memories like the victims of the insominia disease in One Hundred Years of Solitude or something.
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