Dispensaries granted a license to sell marijuana for medical use in Massachusetts will be required to pay an $50,000 annual fee under proposed regulations unveiled Friday by the state Department of Public Health.

The regulations, which also include a $50 annual registration fee for patients to use marijuana, is intended to create a “fee structure for a self-financed medical marijuana industry that supports patient access without relying on taxpayer resources,” according to the state.

Patients with a “verified financial hardship” would be allowed to request a waiver of the registration fee, subject to review and approval by the state health department.